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Writer's pictureAlireza FakhriRavari, PharmD, BCPS, BCIDP, AAHIVP

Males and the elderly more likely to get severe COVID-19?

A recent analysis from CDC looked at a dataset of 1,320,488 laboratory-confirmed COVID-19 cases reported to CDC from January 11, 2020, to May 30, 2020. Previous analyses had determined that age ≥65 years and underlying health conditions such as cardiovascular disease, diabetes, and chronic lung disease were associated with a higher risk for severe infection and lower risk among children aged <18 years.

Insight #1: Males and females are equally likely to get infected in the United States, but males are more likely to get hospitalized, get admitted to the ICU, and die.

While the overall cumulative incidence was 403.6 cases per 100,000 persons, the incidence was 401.1 cases per 100,000 males and 406.0 cases per 100,000 females. Among men, 16% were hospitalized, 3% admitted to the ICU, and 6% died, whereas among women, 12% were hospitalized, 2% admitted to the ICU, and 5% died.

Insight #2: Hospitalizations were 6 times higher in patients with underlying conditions.

Only 287,320 (22%) of cases had sufficient data on underlying conditions. The most common underlying conditions were cardiovascular disease (32%), diabetes (30%), and chronic lung disease (18%). Overall, 14% of patients were hospitalized, 2% were admitted to an ICU, and 5% died. The rate of hospitalization was 45.4% among patients with a reported underlying condition and 7.6% among those without a reported underlying condition. Most ICU admissions were among persons with reported underlying conditions aged 60-69 years (11%) and 70-79 years (12%).

Insight #3: Deaths were 12 times higher in patients with underlying conditions.

Overall, 71,116 patients died, including 19.5% of patients with underlying conditions and 1.6% of those without underlying conditions. Death was most commonly reported among people aged ≥80 years.

Disclaimer: This surveillance dataset represents a subset of the total cases of COVID-19 in the U.S, there are missing data, and asymptomatic cases are not captured well.


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